The OTG-i proprietary imaging methodology is based upon the automated post hoc analysis of digital slit lamp photographs.

Standard magnifications and pre-programmed software settings are used for each of the image types to ensure optimal and consistent lighting levels across all participants. Images are coded in a non-identifiable manner for subsequent masked (eye, visit, treatment etc.) analysis. Proprietary algorithms have been developed and software is used to detect areas of staining and hyperemia. The following ocular tissue responses can be measured using these techniques:

• Corneal fluorescein staining;
• Bulbar conjunctival hyperaemia;
• Palpebral conjunctival hyperaemia;
• Conjunctival lissamine green staining;
• Palpebral and lid margin staining.